Longitudinal changes in body composition during palliative systemic chemotherapy and survival outcomes in metastatic colorectal cancer

Table 3 Univariable and multivariable time-dependent Cox regression analysis

	Univariable		Multivariable
	HR (95%CI)	P value	HR (95%CI)	P value
Body composition (categorical)
Sarcopenia	2.64 (2.16-3.23)	< 0.001	2.55 (2.06-3.16)	< 0.001
Myosteatosis	1.91 (1.67-2.18)	< 0.001	2.37 (2.00-2.82)	< 0.001
Visceral obesity	0.74 (0.65-0.85)	< 0.001	0.69 (0.57-0.82)	< 0.001
Subcutaneous obesity	0.75 (0.66-0.86)	< 0.001	0.78 (0.64-0.95)	0.015
BMI (vs normal)
Obese	0.66 (0.57-0.77)	< 0.001	0.68 (0.56-0.83)	< 0.001
Underweight	2.26 (1.74-2.94)	< 0.001	2.26 (1.75-2.91)	< 0.001
Other clinical variables
Age ≥ 60 years	1.20 (1.06-1.36)	0.004	0.80 (0.69-0.93)	0.004
Female sex (vs male)	1.03 (0.91-1.17)	0.650	0.89 (0.74-1.07)	0.229
Initially metastatic (vs recurrent)	1.28 (1.11-1.47)	0.001	1.43 (1.23-1.66)	< 0.001
Primary tumor location (vs left/rectum)
Right	1.25 (1.08-1.45)	0.003	1.40 (1.17-1.67)	< 0.001
Multifocal/unknown	2.25 (1.41-3.59)	0.001	2.26 (1.54-3.31)	< 0.001
Metastasectomy	0.36 (0.29-0.46)	< 0.001	0.35 (0.28-0.45)	< 0.001
First-line chemotherapy with targeted agent (vs chemotherapy only)	0.44 (0.37-0.52)	< 0.001	0.45 (0.37-0.54)	< 0.001
Lines of treatment (vs 1)
2	1.51 (1.28-1.78)	< 0.001	1.50 (1.24-1.82)	< 0.001
≥ 3	1.29 (1.09-1.53)	0.004	1.20 (0.99-1.46)	0.063
Body composition (continuous)
Sarcopenia T-score	0.69 (0.64-0.74)	< 0.001
Myosteatosis T-score	0.80 (0.77-0.84)	< 0.001
Visceral fat area/100	0.76 (0.67-0.86)	< 0.001
Subcutaneous fat index/10	0.89 (0.86-0.92)	< 0.001
BMI/5	0.60 (0.53-0.67)	< 0.001

BMI: Body mass index; HR: Hazard ratio.