Subclassification scheme for adenocarcinomas of the esophagogastric junction and prognostic analysis based on clinicopathological features

Table 4 Univariate Cox proportional hazards analysis of overall survival

Variable	Hazard ratio	95% confidence interval	P value
This study classification
Type E	1.0		0.002
Type Eg	0.774	0.366-1.640	0.504
Type Ge	0.331	0.167-0.656	0.002
Age
< 65 years	1.0
≥ 65 years	1.110	0.647-1.904	0.705
Sex
Male	1.0
Female	0.850	0.416-1.738	0.657
Tumor size
≤ 40 mm	1.0
> 40 mm	2.235	1.307-3.823	0.003
Esophageal invasion length
< 20 mm	1.0
≥ 20 mm	2.431	1.355-4.362	0.003
Histologic type
Adenocarcinoma	1.0
Mixed adenocarcinoma	2.775	1.102-6.988	0.030
Histological grade
Well-moderately differentiated	1.0
Moderately-poorly differentiated	1.707	0.993-2.936	0.053
Lauren type
Intestinal type	1.0		0.207
Diffuse type	1.776	0.922-3.418	0.086
Mixed type	1.538	0.798-2.964	1.198
Preoperative chemotherapy
No	1.0
Yes	1.484	0.865-2.547	0.152
Vessel invasion
No	1.0
Yes	3.688	2.069-6.573	0.000
Perineural invasion
No	1.0
Yes	2.523	1.420-4.484	0.002
Pathological depth of tumor invasion
T1-2	1.0
T3-4	6.159	2.452-15.471	0.000
Lymph node metastasis
L0	1.0
L1	5.821	2.928-11.570	0.000
Distant metastasis
M0	1.0
M1	2.931	1.053-8.159	0.040