Subclassification scheme for adenocarcinomas of the esophagogastric junction and prognostic analysis based on clinicopathological features

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastrointest Oncol. Apr 15, 2025; 17(4): 103455
Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.103455

Table 2 Comparison of clinicopathological characteristics, mean ± SD

Characteristic	Variables	Type E	Type Eg	Type Ge	P value
Age (year)		61.5 ± 11.7	61.0 ± 9.7	63.0 ± 7.2	0.417
	≤ 65	13	20	62
	> 65	9	11	38	0.922
Sex	Male	18	26	82	0.969
	Female	4	5	18
Tumor size (mm)		53.0 ± 18.2	58.7 ± 12.6	37.9 ± 11.2	0.000^a
	≤ 40 mm	7	4	75	0.000^a
	> 40 mm	15	27	25
Esophageal invasion length (mm)		35.9 ± 13.0	23.9 ± 6.0	5.1 ± 5.4	0.000^a
	< 20 mm	1	0	100	0.000^a
	≥ 20 mm	21	31	0
Surgical approaches	Transthoracic approach	19	8	0	0.000^a
	Transabdominal hiatal approach	3	23	100
Extent of surgical resection	Subtotal esophagectomy with partial gastrectomy	19	8	0	0.000^a
	Proximal gastrectomy with partial esophagectomy	3	5	26
	Total gastrectomy with partial esophagectomy	0	18	74
Histologic type	Adenocarcinoma	18	30	97	0.013^a
	Mixed adenocarcinoma	4	1	3
Histological grade	Well-moderately differentiated	9	8	55	0.016^a
	Moderately-poorly differentiated	12	23	45
Lauren type	Intestinal type	7	6	43	0.150
	Diffuse type	7	13	24
	Mixed type	7	12	32
Preoperative chemotherapy	No	20	19	65	0.042^a
	Yes	2	12	35
Vessel invasion	No	18	24	86	0.512
	Yes	4	7	14
Perineural invasion	No	10	14	49	0.908
	Yes	12	17	51
Pathological depth of tumor invasion	T1-2	6	4	38	0.028^a
	T3-4	16	27	62
Lymph node metastasis	N0	9	7	57	0.003^a
	N1-3	13	24	43
Distant metastasis	M0	21	29	97	0.679
	M1	1	2	3
	I-II	11	8	62	0.002^a
	III-IV	11	23	38
TNM-GC staging system	I-II	11	8	62	0.002^a
	III-IV	11	23	38
TNM-EC staging system	I-II	2	4	27	0.003^a
	III-IV	20	27	63

^aP < 0.05.

TNM: Tumor node metastasis; GC: Gastric cancer; EC: Esophageal cancer.

Citation: Guo S, Liu FF, Yuan L, Ma WQ, Er LM, Zhao Q. Subclassification scheme for adenocarcinomas of the esophagogastric junction and prognostic analysis based on clinicopathological features. World J Gastrointest Oncol 2025; 17(4): 103455
URL: https://www.wjgnet.com/1948-5204/full/v17/i4/103455.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i4.103455

Guo S, Liu FF, Yuan L, Ma WQ, Er LM, Zhao Q. Subclassification scheme for adenocarcinomas of the esophagogastric junction and prognostic analysis based on clinicopathological features. World J Gastrointest Oncol 2025; 17(4): 103455 [PMID: 40235906 DOI: 10.4251/wjgo.v17.i4.103455]

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