Hypercoagulation after neoadjuvant immunochemotherapy as a new prognostic indicator in patients with locally advanced gastric cancer undergoing surgery

Table 3 Preoperatively determined prognostic factors for disease-free survival in locally advanced gastric cancer

Variable	Univariate			Multivariate
	Hazard ratio	95%CI	P value	Hazard ratio	95%CI	P value
Gender			0.747
Male	Reference
Female	1.177	0.437-3.172
Age (years)			0.108
< 66	Reference
≥ 66	1.988	0.859-4.598
Smoking history			0.874
Never smoker	Reference
Ever smoker	0.927	0.365-2.352
Drinking history			0.745
Never drinker	Reference
Ever drinker	1.196	0.406-3.520
BMI (kg/m2)			0.998
< 22	Reference
≥ 22	1.001	0.438-2.286
Tumor location			0.951
Upper stomach	Reference
Middle stomach	0.850	0.242-2.984	0.800
Lower stomach	0.890	0.355-2.232	0.804
Vascular invasion			0.088
Yes	Reference
No	2.074	0.897-4.798
Neurological invasion			0.038			0.044
Yes	Reference			Reference
No	2.432	1.051-5.627		2.372	1.024-5.492
Clinical T stage			0.066
cT3	Reference
cT4	0.459	0.200-1.054
Clinical N stage			0.744
cN1	Reference
cN2-3	1.154	0.489-2.722
Pathological type			0.439
Non- signet ring cell carcinoma	Reference
Signet ring cell carcinoma	1.445	0.569-3.669
Hypercoagulation			0.034			0.039
No	Reference			Reference
Yes	2.611	1.073-6.356		2.551	1.047-6.217

CI: Confidence interval; BMI: Body mass index.