Hypercoagulation after neoadjuvant immunochemotherapy as a new prognostic indicator in patients with locally advanced gastric cancer undergoing surgery

Table 2 Preoperatively determined prognostic factors for overall survival in locally advanced gastric cancer

Variable	Univariate			Multivariate
	Hazard ratio	95%CI	P value	Hazard ratio	95%CI	P value
Gender			0.587
Male	Reference
Female	0.660	0.147-2.956
Age (years)			0.138
< 66	Reference
≥ 66	2.235	0.773-6.464
Smoking history			0.682
Never smoker	Reference
Ever smoker	0.766	0.213-2.753
Drinking history			0.922
Never drinker	Reference
Ever drinker	1.078	0.240-4.844
BMI (kg/m2)			0.670
< 22	Reference
≥ 22	0.796	0.278-2.279
Tumor location			0.593
Upper stomach	Reference
Middle stomach	1.556	0.410-5.904	0.516
Lower stomach	0.676	0.178-2.567	0.565
Vascular invasion			0.079
Yes	Reference
No	2.662	0.893-7.934
Neurological invasion			0.015			0.055
Yes	Reference			Reference
No	4.324	1.328-14.079		3.329	0.975-11.366
Clinical T stage			0.109
cT3	Reference
cT4	2.494	0.815-7.625
Clinical N stage			0.258
cN1	Reference
cN2-3	1.851	0.637-5.381
Pathological type			0.024			0.082
Non- signet ring cell carcinoma	Reference			Reference
Signet ring cell carcinoma	3.428	1.177-9.981		2.694	0.882-8.231
Hypercoagulation			0.031			0.023
No	Reference			Reference
Yes	4.078	1.136-14.643		4.436	1.227-16.045

CI: Confidence interval; BMI: Body mass index.