Metastatic lymph node distribution and pathology correlations in upper and lower gastric cancer patients: A multicenter retrospective study

Table 4 Cox regression models analysis of prognostic risk factors in gastric cancer

Variables	Univariate analysis			Multivariable analysis
	HR	95%CI	P value	HR	95%CI	P value
Gender
Male	1.000
Female	1.106	0.976–1.254	0.114
Age (year)
< 60	1.000			1.000
≥ 60	1.419	1.246-1.617	< 0.001a	1.594	1.395-1.821	< 0.001a
Tumor diameter (cm)
< 4	1.000
≥ 4	1.142	0.747-1.746	0.534
Tumor location
Upper	1.000			1.000
Lower	1.302	1.158-1.464	< 0.001a	1.049	0.921-1.195	0.473
Pathological type
Other	1.000			1.000
Adenocarcinoma	1.400	0.933-2.100	0.094	1.566	1.039-2.362	0.032a
Signet-ring cell carcinoma	1.490	0.974-2.280	0.066	1.586	1.027-2.450	0.037a
Histological grade
G1	1.000			1.000
G2	1.457	1.096-1.938	0.010a	1.087	0.814-1.453	0.571
G3	1.943	1.481-2.549	< 0.001a	1.201	0.905-1.593	0.204
pT stage
T1	1.000			1.000
T2	1.577	1.257-1.979	< 0.001a	1.205	0.946-1.534	0.130
T3	2.566	2.153-3.059	< 0.001a	1.411	1.128-1.766	0.003a
T4	3.864	3.194-4.676	< 0.001a	1.801	1.395-2.326	< 0.001a
pN stage
N0	1.000			1.000
N1	1.715	1.464-2.009	< 0.001a	1.328	1.083-1.628	0.006a
N2	2.441	2.059-2.893	< 0.001a	1.645	1.282-2.111	< 0.001a
N3	3.505	2.989-4.110	< 0.001a	2.148	1.666-2.768	< 0.001a
pTNM stage
I	1.000			1.000
II	1.383	1.102-1.735	0.005a	1.223	0.958-1.563	0.107
III	2.651	2.331-3.015	< 0.001a	1.812	1.395-2.354	< 0.001a
Surgery type
PG	1.000
TG	1.147	0.987-1.333	0.124
Vascular invasion
Negative	1.000			1.000
Positive	2.440	2.136-2.787	< 0.001a	1.813	1.512-2.218	< 0.001a
Chemotherapy
Yes	1.000			1.000
NO	1.433	1.271-1.616	< 0.001a	1.670	1.460-1.910	< 0.001a

^aP < 0.05.

HR: Hazard ratio; PG: Partial gastrectomy; TG: Total gastrectomy; TNM: Tumor-node-metastasis.