Prognostic significance of preoperative C-reactive protein-triglyceride-glucose index in long-term outcomes after radical gastrectomy for gastric cancer

Table 3 Univariate and multivariate analyses of prognostic factors for overall survival

Variables	Univariate		Multivariate
	P value	HR (95%CI)	P value	HR (95%CI)
Gender
Female		1.00 (Ref.)
Male	0.667	1.14 (0.63-2.04)
Age
< 50		1.00 (Ref.)
≥ 50	0.346	1.31 (0.75-2.27)
AT
No		1.00 (Ref.)		1.00 (Ref.)
Yes	0.015	0.51 (0.29-0.88)	< 0.001	0.15 (0.08-0.30)
T stage
T1		1.00 (Ref.)
T2	0.016	4.84 (1.35-17.36)
T3	0.017	4.24 (1.29-13.96)
T4	0.006	5.53 (1.62-18.88)
N stage
N0		1.00 (Ref.)		1.00 (Ref.)
N1	0.028	2.89 (1.12-7.46)	0.001	5.87 (2.02-17.06)
N2	0.003	4.09 (1.63-10.26)	< 0.001	6.53 (2.48-17.18)
N3	< 0.001	5.83 (2.55-13.36)	< 0.001	12.18 (4.65-31.91)
LN meta
No		1.00 (Ref.)
Yes	< 0.001	3.20 (1.62-6.32)
CTI
< 9.07		1.00 (Ref.)		1.00 (Ref.)
≥ 9.07	< 0.001	2.77 (1.63-4.73)	0.001	2.47 (1.44-4.23)
PNI	< 0.001	0.90 (0.86-0.94)	< 0.001	0.91 (0.87-0.95)
CEA	0.884	1.00 (0.99-1.01)
CA199	0.004	1.01 (1.01-1.01)

HR: Hazards ratio; CI: Confidence interval; AT: Adjuvant therapy; T: Tumor; N: Node; LN meta: Lymph node metastasis; CTI: C-reactive protein-triglyceride-glucose index; PNI: Prognostic nutritional index; CEA: Carcinoembryonic antigen; CA199: Carbohydrate antigen 199.