Prognostic significance of preoperative C-reactive protein-triglyceride-glucose index in long-term outcomes after radical gastrectomy for gastric cancer

Table 2 Univariate and multivariate analyses of prognostic factors for disease-free survival

Variables	Univariate		Multivariate
	P value	HR (95%CI)	P value	HR (95%CI)
Gender
Female		1.00 (Ref.)
Male	0.956	1.01 (0.64-1.59)
Age
< 50		1.00 (Ref.)
≥ 50	0.592	0.89 (0.59-1.35)
AT times
0		1.00 (Ref.)		1.00 (Ref.)
1-3	0.011	2.06 (1.18-3.60)	0.779	0.91 (0.48-1.72)
4	0.022	0.56 (0.34-0.92)	< 0.001	0.17 (0.09-0.31)
T stage
T1		1.00 (Ref.)		1.00 (Ref.)
T2	0.057	2.59 (0.97-6.91)	0.110	2.28 (0.83-6.28)
T3	< 0.001	4.24 (1.81-9.89)	0.001	4.78 (1.88-12.20)
T4	< 0.001	5.16 (2.13-12.52)	0.004	4.62 (1.65-12.94)
N stage
N0		1.00 (Ref.)		1.00 (Ref.)
N1	0.356	1.36 (0.71-2.60)	0.112	1.79 (0.87-3.66)
N2	0.002	2.59 (1.42-4.72)	< 0.001	3.10 (1.62-5.93)
N3	< 0.001	2.76 (1.61-4.73)	< 0.001	3.49 (1.76-6.92)
LN meta
No		1.00 (Ref.)
Yes	0.002	2.06 (1.30-3.27)
CTI
< 9.07		1.00 (Ref.)		1.00 (Ref.)
≥ 9.07	< 0.001	2.46 (1.63-3.71)	< 0.001	2.07 (1.36-3.17)
PNI	< 0.001	0.93 (0.90-0.97)	0.044	0.96 (0.92-0.99)
CEA	0.937	1.00 (0.99-1.01)
CA199	0.040	1.01 (1.01-1.01)

HR: Hazards ratio; CI: Confidence interval; AT: Adjuvant therapy; T: Tumor; N: Node; CTI: C-reactive protein-triglyceride-glucose index; PNI: Prognostic nutritional index; CEA: Carcinoembryonic antigen; CA199: Carbohydrate antigen 199; LN meta: Lymph node metastasis.