Lymphocyte to C-reactive protein ratio as a novel inflammatory biomarker: Validation and clinical relevance as an independent prognostic factor in cholangiocarcinoma

Table 2 Univariate and multivariate analyses of surgical site infection predictors

Variables	Univariate			Multivariate
	OR	95%CI	P value	OR	95%CI	P value
Age
> 70	2.436	0.628-9.448	0.098	2.520	0.592-10.734	0.211
Sex
Female	2.400	0.872-6.603	0.190
Obstructive jaundice
Yes	2.600	0.932-7.255	0.068	2.437	0.707-8.394	0.158
CEA
Abnormal	1.007	0.367-2.761	0.989
CA199
Abnormal	1.978	0.695-5.626	0.201
CA125
Abnormal	1.800	0.638-5.081	0.267
CRP
Abnormal	1.156	0.423-3.158	0.778
WBC count (109/L)
Abnormal	1.034	0.382-2.799	0.947
Albumin (g/L)
Abnormal	1.824	0.598-5.564	0.291
Hemoglobin (g/L)
Abnormal	2.443	0.722-8.265	0.151
Tumor location
Intrahepatic	2.423	0.835-7.028	0.099	2.094	0.568-7.726	0.267
Number of tumors
≥ 2	1.700	0.264-10.947	0.577
Tumor size
Largest diameter ≥ 5 cm	1.312	0.421-4.090	0.639
Surrounding vascular invasion
Yes	1.575	0.455-5.457	0.474
Surrounding tissues invasion
Yes	1.975	0.552-7.065	0.295
Lymph node metastasis
Yes	1.697	0.573-5.028	0.340
Tumor stage
III	1.292	0.478-3.494	0.613
Tumor grade
III vs II vs I	1.050	0.501-2.2	0.897
R0 resection
Yes	1.739	0.339-8.390	0.507
LCR
Low	3.438	0.901-13.125	0.071	4.412	1.035-18.806	0.045

OR: Odds ratio; CI: Confidence interval; CEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; CRP: C-reactive protein; WBC: White blood cell; LCR: Lymphocyte to C-reactive protein ratio.