©The Author(s) 2025.
World J Gastrointest Oncol. Dec 15, 2025; 17(12): 113853
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.113853
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.113853
Table 1 Clinicopathological characteristics of 76 patients with cholangiocarcinoma, n (%)
| Variables | Number of patients | Low LCR | High LCR | P value |
| Age | 0.287 | |||
| ≤ 70 | 58 (76.32) | 43 (56.58) | 15 (19.74) | |
| > 70 | 18 (23.68) | 11 (14.47) | 7 (9.21) | |
| Sex | 0.870 | |||
| Male | 46 (60.53) | 33 (43.42) | 13 (17.11) | |
| Female | 30 (39.47) | 21 (27.63) | 9 (11.84) | |
| Obstructive jaundice | 0.432 | |||
| Yes | 50 (65.79) | 37 (48.7) | 13 (17.1) | |
| No | 26 (34.21) | 17 (22.4) | 9 (11.8) | |
| CEA | 0.989 | |||
| Normal | 45 (59.21) | 32 (42.1) | 13 (17.1) | |
| Abnormal | 31 (40.79) | 22 (28.9) | 9 (11.8) | |
| CA199 | ||||
| Normal | 23 (30.26) | 17 (22.4) | 6 (7.9) | 0.717 |
| Abnormal | 53 (69.74) | 37 (48.7) | 16 (21.1) | |
| CA125 | 0.606 | |||
| Normal | 52 (68.42) | 36 (47.4) | 16 (21.1) | |
| Abnormal | 24 (31.58) | 18 (23.7) | 6 (7.9) | |
| CRP | < 0.001a | |||
| Normal | 33 (43.42) | 11 (14.5) | 22 (28.9) | |
| Abnormal | 43 (56.58) | 43 (56.6) | 0 (0.0) | |
| WBC count (109/L) | 0.343 | |||
| Normal | 35 (46.05) | 23 (30.3) | 12 (15.8) | |
| Abnormal | 41 (53.95) | 31 (40.8) | 10 (13.2) | |
| Albumin (g/L) | 0.471 | |||
| Normal | 58 (76.32) | 40 (52.6) | 18 (23.7) | |
| Abnormal | 18 (23.68) | 14 (18.4) | 4 (5.3) | |
| Hemoglobin (g/L) | 0.851 | |||
| Normal | 23 (30.26) | 16 (21.1) | 7 (9.2) | |
| Abnormal | 53 (69.74) | 38 (50.0) | 15 (19.7) | |
| Tumor location | 0.277 | |||
| Intrahepatic | 21 (27.63) | 13 (17.1) | 8 (10.5) | |
| Extrahepatic | 55 (72.37) | 41 (53.9) | 14 (18.4) | |
| Number of tumor | ||||
| 1 | 71 (93.42) | 51 (67.1) | 20 (26.3) | 0.573 |
| ≥ 2 | 5 (6.58) | 3 (3.9) | 2 (2.6) | |
| Tumor size | 0.900 | |||
| Largest diameter ≥ 5 cm | 18 (23.68) | 13 (17.1) | 5 (6.6) | |
| Largest diameter < 5 cm | 58 (76.32) | 41 (53.9) | 17 (22.4) | |
| Surrounding vascular invasion | 0.188 | |||
| Yes | 18 (23.68) | 15 (19.7) | 3 (3.9) | |
| No | 58 (76.32) | 39 (51.3) | 19 (25.0) | |
| Surrounding tissues invasion | 0.307 | |||
| Yes | 64 (84.21) | 44 (57.9) | 20 (26.3) | |
| No | 12 (15.79) | 10 (13.2) | 2 (2.6) | |
| Lymph node metastasis | 0.666 | |||
| Yes | 27 (35.52) | 20 (26.3) | 7 (9.2) | |
| No | 49 (64.48) | 34 (44.7) | 15 (19.7) | |
| Tumor stage | ||||
| II | 38 (50.00) | 27 (34.5) | 11 (14.5) | 1.0 |
| III | 38 (50.00) | 27 (34.5) | 11 (14.5) | |
| Tumor grade | 0.404 | |||
| I | 26 (34.21) | 16 (21.1) | 10 (13.2) | |
| II | 39 (51.32) | 30 (39.5) | 9 (11.8) | |
| III | 11 (14.47) | 8 (10.5) | 3 (3.9) | |
| R0 resection | 0.115 | |||
| Yes | 66 (86.84) | 49 (64.5) | 17 (22.3) | |
| No | 10 (13.16) | 5 (6.6) | 5 (6.6) |
- Citation: Xiao F, Zhou DH, Liu GW, Lin CW, Wu ZY, Yu H, Gong W, Tan WF. Lymphocyte to C-reactive protein ratio as a novel inflammatory biomarker: Validation and clinical relevance as an independent prognostic factor in cholangiocarcinoma. World J Gastrointest Oncol 2025; 17(12): 113853
- URL: https://www.wjgnet.com/1948-5204/full/v17/i12/113853.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v17.i12.113853