Clinical characteristics and prognostic analysis of three hundred and nineteen cases of primary gastrointestinal diffuse large B-cell lymphoma

Table 3 Univariate and multivariate Cox regression analyses of factors associated with overall survival in the training cohort (n = 223)

Characteristic	Category	Univariate analysis		Multivariate analysis
		HR (95%CI)	P value	HR (95%CI)	P value
Age (year)	≤ 60	Reference	-	Reference	-
	> 60	1.49 (1.01-2.21)	0.045	1.34 (0.90-2.02)	0.153
Gender	Male	Reference	-	NA	NA
	Female	1.27 (0.86-1.89)	0.232	NA	NA
ECOG PS ≥ 2	0-1	Reference	-	Reference	-
	≥ 2	1.52 (1.03-2.25)	0.034	1.52 (0.96-2.41)	0.075
Extranodal sites ≥ 2	No	Reference	-	NA	NA
	Yes	1.00 (0.68-1.48)	0.992	NA	NA
β2-MG (mg/L)	≤ 2.2	Reference	-	Reference	-
	> 2.2	1.56 (1.05-2.31)	0.029	1.39 (0.91-2.11)	0.126
LDH (U/L)	≤ 250	Reference	-	Reference	-
	> 250	0.65 (0.44-0.95)	0.028	0.79 (0.52-1.20)	0.266
B symptoms	No	Reference	-	Reference	-
	Yes	1.64 (1.08-2.48)	0.019	1.56 (1.00-2.41)	0.048
Lesion type	Ulcerative	Reference	-	Reference	-
	Mixed	0.23 (0.10-0.53)	< 0.001	0.21 (0.09-0.49)	< 0.001
	Raised	1.09 (0.64-1.87)	0.742	1.14 (0.65-1.98)	0.647
	Diffuse	1.62 (0.99-2.64)	0.053	1.30 (0.77-2.21)	0.331
Tissue origin	Endoscopic (1)	Reference	-	NA	NA
	Abdominal mass (3)	1.27 (0.80-2.01)	0.307	NA	NA
	Surgical (2)	0.81 (0.49-1.34)	0.405	NA	NA
BCL-6	Negative	Reference	-	NA	NA
	Positive	0.72 (0.49-1.07)	0.104	NA	NA
MUM-1	Positive	Reference	-	Reference	-
	Negative	0.68 (0.46-1.02)	0.062	0.63 (0.41-0.97)	0.034
CD5	Negative	Reference	-	NA	NA
	Positive	0.73 (0.49-1.09)	0.122	NA	NA

Statistically significant values (P < 0.05) are highlighted in bold. Not available indicates variables not included in the multivariate Cox regression model. CI: Confidence interval; HR: Hazard ratio; ECOG PS: Eastern Cooperative Oncology Group Performance Status; β2-MG: Β2-microglobulin; LDH: Lactate dehydrogenase; BCL-6: B-cell lymphoma 6; MUM-1: Multiple myeloma oncogene 1; NA: Not available.