Molecular mechanism of non-coding RNAs-mediated radiosensitivity regulation in colorectal cancer

Table 1 Several microRNAs involved in radiosensitivity of colorectal cancer

MicroRNAs	Target	Radiosensitivity	Ref.
miR-141-3p	DLX6-AS1	Increase	[55]
miR-630	BCL2 L2	Increase	[56]
let-7e	IGF-1R	Increase	[57]
miR-31	STK40	Increase	[58]
miR-124	PRRX1	Increase	[59,60]
miR-378a-5p	LRP8	Increase	[61]
miR-183-5p	ATG5	Decrease	[62]
miR-622	RB1	Decrease	[63]
miR-29a	PTEN	Decrease	[63]
miR-93-5p	FOXA1	Decrease	[64]
miR-19b	FBXW7	Decrease	[65]
miR-106b	PTEN and p21	Decrease	[66]
miR-222	PTEN	Decrease	[67]
miR-4274	PEX5	Increase	[68]
miR-130a	SOX4	Increase	[69]
miR-1226-5p	IRF1	Decrease	[70]

DLX6-AS1: Distal-less homeobox 6 antisense 1; BCL2 L2: BCL2-like 2; IGF-1R: Insulin-like growth factor-1 receptor; STK40: Serine threonine kinase 40; PRRX1: Paired-related homeobox 1; LRP8: Low density lipoprotein receptor related protein 8; ATG5: Autophagy related 5; RB1: RB transcriptional corepressor 1; PTEN: Phosphatase and tensin homolog; FOXA1: Forkhead box protein A1; FBXW7: F-box and WD repeat domain-containing protein 7; p21: Cyclin-dependent kinase inhibitor 1A; PEX5: Peroxisomal biogenesis factor 5; SOX4: SRY-related high-mobility-group box 4; IRF1: Interferon regulatory factor 1.