Optimized digital polymerase chain reaction enables detection of telomerase reverse transcriptase C228T mutation for prognostic assessment in hepatocellular carcinoma

doi:10.4251/wjgo.v17.i12.113289

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Dec 15, 2025; 17(12): 113289
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.113289

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Figure 8 Decision curve analysis. A-C: Overall survival; D-F: Disease-free survival. Decision curve analysis showed the 1-, 2-, and 5-year predictive efficiency of the overall survival and disease-free survival nomogram model. OS: Overall survival; DFS: Disease-free survival; TERT: Telomerase reverse transcriptase; AFP: Alpha fetoprotein; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transferase; MVI: Microvascular invasion; BVI: Blood vessel invasion.

Citation: Aizimuaji Z, Hu N, Li HY, Wang XJ, Ma S, Wang YR, Zheng RQ, Li Z, Zhao H, Rong WQ, Xiao T. Optimized digital polymerase chain reaction enables detection of telomerase reverse transcriptase C228T mutation for prognostic assessment in hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(12): 113289
URL: https://www.wjgnet.com/1948-5204/full/v17/i12/113289.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i12.113289

Aizimuaji Z, Hu N, Li HY, Wang XJ, Ma S, Wang YR, Zheng RQ, Li Z, Zhao H, Rong WQ, Xiao T. Optimized digital polymerase chain reaction enables detection of telomerase reverse transcriptase C228T mutation for prognostic assessment in hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(12): 113289 [PMID: 41480220 DOI: 10.4251/wjgo.v17.i12.113289]

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