Optimized digital polymerase chain reaction enables detection of telomerase reverse transcriptase C228T mutation for prognostic assessment in hepatocellular carcinoma

Figure 6 Construction and validation of overall survival and disease-free survival nomograms. A and B: The prognostic performance between the telomerase reverse transcriptase mutation status and different conventional clinical characteristics was compared by calculating the overall survival (OS) and disease-free survival (DFS) C-index. The maximum C-index of the OS and DFS nomogram model was 0.7651 and 0.6899, respectively. The maximum C-index of telomerase reverse transcriptase (TERT) mutation in OS and DFS was 0.6224 and 0.6228, respectively; C: OS-nomogram was used to predict aspartate aminotransferase, gamma-glutamyl transferase, microvascular invasion, blood vessel invasion and TERT mutation status; D: DFS-nomogram was used to predict gamma-glutamyl transferase, blood vessel invasion and TERT mutation status; E and F: Receiver operating characteristic curves showed the 1-, 2-, and 5-year predictive efficiency of the OS and DFS nomogram model. OS: Overall survival; DFS: Disease-free survival; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transferase; AFP: Alpha fetoprotein; MVI: Microvascular invasion; BVI: Blood vessel invasion; TERT: Telomerase reverse transcriptase; AUC: Areas under the curve; TPR: True positive rate; FPR: False positive rate.