Optimized digital polymerase chain reaction enables detection of telomerase reverse transcriptase C228T mutation for prognostic assessment in hepatocellular carcinoma

doi:10.4251/wjgo.v17.i12.113289

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Dec 15, 2025; 17(12): 113289
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.113289

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Figure 5 Kaplan-Meier curves based on telomerase reverse transcriptase C228T mutation status and alpha fetoprotein level. A and B: Kaplan-Meier curve of overall survival (OS; P = 0.028) and disease-free survival (DFS; P = 0.002) in telomerase reverse transcriptase C228T mutated patients; C and D: Kaplan-Meier curve of OS (P = 0.004) and DFS (P = 0.278) stratified by alpha fetoprotein; E and F: The telomerase reverse transcriptase C228T mutated patient’s OS (P = 0.005) and DFS (P = 0.01) stratified by alpha fetoprotein. TERT: Telomerase reverse transcriptase; HR: Hazard ratio; AFP: Alpha fetoprotein.

Citation: Aizimuaji Z, Hu N, Li HY, Wang XJ, Ma S, Wang YR, Zheng RQ, Li Z, Zhao H, Rong WQ, Xiao T. Optimized digital polymerase chain reaction enables detection of telomerase reverse transcriptase C228T mutation for prognostic assessment in hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(12): 113289
URL: https://www.wjgnet.com/1948-5204/full/v17/i12/113289.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i12.113289

Aizimuaji Z, Hu N, Li HY, Wang XJ, Ma S, Wang YR, Zheng RQ, Li Z, Zhao H, Rong WQ, Xiao T. Optimized digital polymerase chain reaction enables detection of telomerase reverse transcriptase C228T mutation for prognostic assessment in hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(12): 113289 [PMID: 41480220 DOI: 10.4251/wjgo.v17.i12.113289]

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