Optimized digital polymerase chain reaction enables detection of telomerase reverse transcriptase C228T mutation for prognostic assessment in hepatocellular carcinoma

doi:10.4251/wjgo.v17.i12.113289

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Dec 15, 2025; 17(12): 113289
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.113289

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Figure 1 Schematic representation of the commonly mutated nucleotides C228T (124 bp) and C250T (146 bp) in relation to the telomerase reverse transcriptase promoter positions and the genomic positions within chromosomal region 5 p15. 33. TSS: Transcriptional start site; ATG: Adenine-thymine-guanine; TERT: Telomerase reverse transcriptase.

Citation: Aizimuaji Z, Hu N, Li HY, Wang XJ, Ma S, Wang YR, Zheng RQ, Li Z, Zhao H, Rong WQ, Xiao T. Optimized digital polymerase chain reaction enables detection of telomerase reverse transcriptase C228T mutation for prognostic assessment in hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(12): 113289
URL: https://www.wjgnet.com/1948-5204/full/v17/i12/113289.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i12.113289

Aizimuaji Z, Hu N, Li HY, Wang XJ, Ma S, Wang YR, Zheng RQ, Li Z, Zhao H, Rong WQ, Xiao T. Optimized digital polymerase chain reaction enables detection of telomerase reverse transcriptase C228T mutation for prognostic assessment in hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(12): 113289 [PMID: 41480220 DOI: 10.4251/wjgo.v17.i12.113289]

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