Pancreatic neuroendocrine microtumors in the elderly: A retrospective study using cadaveric pancreatic tissue

Figure 3 Histopathological changes of pancreatic neuroendocrine microtumors in Case 5. A: Hematoxylin and eosin staining of pancreatic neuroendocrine microtumors (PNEMTs) of Case 5; B: Immunostaining of PNEMTs in A with chromogranin A antibody; C: Immunostaining of PNEMTs with glucagon (GLU) antibody; D: Immunostaining of PNEMTs with Ki-67 antibody. Black arrows in A and B: Indicate that the outer layer of the tumor was surrounded by a thick fibrotic wall; Black asterisk in A: Fatty degeneration; white two asterisks in A: Fibrosis; Black arrows in C: GLU-positive PNEMTs cells; Black arrows in D: A small number of Ki-67-positive PNEMTs cells. CGA: Chromogranin A; GLU: Glucagon.