Pancreatic neuroendocrine microtumors in the elderly: A retrospective study using cadaveric pancreatic tissue

Figure 1 Histopathological changes of 3 cases of pancreatic neuroendocrine microtumors. A: Hematoxylin and eosin (H&E) staining of pancreatic neuroendocrine microtumors (PNEMTs) of Case 1; B: Immunostaining of PNEMTs in A with chromogranin A (CGA) antibody; C: H&E staining of PNEMTs of Case 2; D: H&E staining of PNEMTs in C; E: H&E staining of PNEMTs of Case 3; F: Immunostaining of PNEMTs in E with glucagon antibody. White arrows, PNEMTs. Although PNEMTs was not found to have infiltrated into the pancreatic tissue, the black arrows (in A-C) indicated a slight membrane structure between PNEMTs and the pancreatic tissue. Black asterisk in A: Fatty degeneration; black arrows in B: CGA-positive cells; black asterisk in E: Acinar ductal metaplasia; white asterisk in E: Fibrosis with inflammation cell infiltration; black arrows in D: The tumors exhibited an organoid-like architecture, with tumor cells arranged in a trabecular pattern. a: Artery; L: Islets of Langerhans; PD: Pancreatic duct; v: Vein; CGA: Chromogranin A; GLU: Glucagon.