Clinical significance of citrullinated glial fibrillary acidic protein in predicting outcomes in hepatocellular carcinoma

Table 3 Univariate and multivariate Cox regression analyses for recurrence following surgical treatment in hepatocellular carcinoma patients

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Age (years)	1.002	0.982-1.022	0.845
Sex (male/female)	0.932	0.487-1.787	0.833
DM	0.864	0.512-1.458	0.583
HTN	1.237	0.768-1.994	0.381
HBsAg-positive (+)	0.965	0.576-1.617	0.892
LC	0.959	0.592-1.552	0.863
Child-Pugh class (B/A)	2.196	0.947-5.090	0.067
Tumor size (≥ 5 cm/< 5 cm)	2.493	1.503-4.136	< 0.001	2.378	1.426-3.965	< 0.001
Tumor number (single vs multiple)	1.173	0.650-2.120	0.596
Edmonson-Steiner (1, 2/3, 4)	1.223	0.735-2.037	0.493
Platelet	0.999	0.996-1.003	0.646
Serum ALT (IU/L)	1.009	1.001-1.017	0.032	1.007	0.999-1.015	0.081
AFP > 400	1.643	0.824-2.793	0.181
cit-GFAP (high/Low)	1.456	0.895-2.369	0.130

DM: Diabetes mellitus; HTN: Hypertension; HBsAg: Hepatitis B surface antigen; LC: Liver cirrhosis; ALT: Alanine aminotransferase; AFP: Alpha-fetoprotein; cit-GFAP: Citrullinated glial fibrillary acidic protein; HR: Hazard ratio; CI: Confidence interval.