Clinical significance of citrullinated glial fibrillary acidic protein in predicting outcomes in hepatocellular carcinoma

Table 2 Univariate and multivariate Cox regression analyses for mortality following surgical treatment in hepatocellular carcinoma patients

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Age (years)	1.021	0.981-1.062	0.312
Sex (male/female)	1.274	0.363-4.475	0.705
DM	0.871	0.308-2.461	0.794
HTN	0.869	0.349-2.164	0.762
HBsAg-positive (+)	0.494	0.199-1.221	0.127
LC	0.954	0.387-2.349	0.918
Child-Pugh class (B/A)	2.192	0.504-9.542	0.296
Tumor size (≥ 5 cm/< 5 cm)	3.323	1.315-8.398	0.011	2.967	1.097-8.024	0.032
Tumor number (single vs multiple)	2.270	0.882-5.842	0.089
Edmonson-Steiner (1, 2/3, 4)	2.318	0.759-7.083	0.140
Platelet	1.003	0.995-1.010	0.493
Serum ALT (IU/L)	1.010	0.995-1.025	0.208
AFP > 400	2.736	1.025-7.303	0.045	1.696	0.5691-4.863	0.326
cit-GFAP (high/Low)	2.707	1.006-7.290	0.049	2.753	1.015-7.464	0.047

DM: Diabetes mellitus; HTN: Hypertension; HBsAg: Hepatitis B surface antigen; LC: Liver cirrhosis; ALT: Alanine aminotransferase; AFP: Alpha-fetoprotein; cit-GFAP: Citrullinated glial fibrillary acidic protein; HR: Hazard ratio; CI: Confidence interval.