Clinical significance of citrullinated glial fibrillary acidic protein in predicting outcomes in hepatocellular carcinoma

Table 1 Baseline characteristics according to citrullinated glial fibrillary acidic protein expression, mean ± SD/n (%)

Variables	Total (n = 169)	Low (n = 87)	High (n = 82)	P value
Age (years)	62.49 ± 12.15	63.03 ± 10.76	61.83 ± 13.47	0.520
Sex (male)	137 (81.1)	76 (87.4)	61 (74.3)	0.032
HBsAg-positive (+)	115 (68.5)	66 (75.9)	49 (60.5)	0.032
DM	53 (31.4)	28 (32.2)	25 (30.4)	0.812
HTN	78 (46.2)	40 (46.0)	38 (46.3)	0.962
LC	92 (54.4)	53 (60.9)	39 (47.5)	0.081
Child-Pugh class (B/A)	13/156	5/82	8/74	0.328
Tumor size (≥ 5 cm/< 5 cm)	47/122	24/63	23/59	0.947
Tumor number	1.24 ± 0.612	1.22 ± 0.53	1.26 ± 0.08	0.230
PVI	65 (38.7)	28 (32.2)	37 (45.7)	0.073
Edmonson-Steiner (1, 2/3, 4)	52/116	33/54	19/63	0.038
WBC	5800 (1100-24400)	5700 (1100-19600)	6742 (1700-24400)	0.271
Platelet	167 (22-401)	157 (22-401)	175 (34-401)	0.169
Serum ALT (IU/L)	28 (8-235)	28 (11-140)	28 (8-235)	0.276
Total bilirubin	0.64 (0.20-9.30)	0.64 (0.30-2.80)	0.65 (0.20-9.30)	0.662
Albumin	4.2 (2.3-5.5)	4.2 (2.7-5.5)	4.3 (2.3-5.2)	0.504
PT-INR	1.04 (0.87-1.63)	1.06 (0.88-1.63)	1.02 (0.87-1.56)	0.079
AFP > 400	29 (17.3)	14 (16.1)	15 (18.2)	0.705

HBsAg: Hepatitis B surface antigen; DM: Diabetes mellitus; HTN: Hypertension; LC: Liver cirrhosis; PVI: Perivascular invasion; WBC: White blood counts; ALT: Alanine aminotransferase; PT-INR: Prothrombin time and international normalized ratio; AFP: Alpha-fetoprotein.