Transient receptor potential melastatin 6 and transient receptor potential melastatin 6/7 antagonists suppress colon adenocarcinoma HT-29 cells

Figure 4 Transient receptor potential melastatin inhibitors affect spheroid stability. A-E: Cancer spheroids treated with or without Co(III)hexamine, representative images, percent integrated density, percent spheroid area, Feret diameter, perimeter; F-J: Cancer spheroids treated with or without 2-aminoethyl diphenylborinate, representative images, percent integrated density, percent spheroid area, Feret diameter, perimeter; K-O: Cancer spheroids treated with or without Mesendogen, representative images, percent integrated density, percent spheroid area, Feret diameter, perimeter. Scale bar = 200 μm. SP: Spheroid; Co(III)hex: Co(III)hexamine; 2-APB: 2-aminoethyl diphenylborinate; ME: Mesendogen. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 vs the same grout at time 0 hour (n = 6).