Transient receptor potential melastatin 6 and transient receptor potential melastatin 6/7 antagonists suppress colon adenocarcinoma HT-29 cells

Table 2 Phosphorylated residue of transient receptor potential melastatin 7 proteins

	Parental HT-29	Spheroid-derived HT-29
N-terminus	S9, T10, T12, Y18, S22, S23, T55, S57, Y62, S79, T84, S87, T89, S101, S103, Y104, Y108, S113, T115, S138, S193, S196, S233, S243, Y256, T270, Y303, T318, Y327, T332, T349, T353, S359, T379, S385, T397, S406, Y430, S453, S464, T470, Y505, T508, Y528, S539, S547, S552, S554, S561, T564, T583, Y587, T603, T615, S648, S683, T737, T739, S745, T778, S788, T807 S823, S824, S836, Y849	S2, S9, T10, Y18, S22, S23, T55, S57, Y62, S63, S74, S79, S87, T89, Y92, S101, S103, Y108, S112, Y113, T115, S138, T166, T167, T173, S195, S196, T201, Y225, T227, S243, T252, T269, T318, T332, T353, S359, T367, T379, Y430, S438, S453, S464, T508, S539, S547, S552, S553, S554 T555, S561, T564, T583, Y587, T603, T615, S648, S661, S676, S727, S728, T778, S783, S788, T795, S799, S823, S824, S836, Y849, T860, Y863
Channels	T895, Y896, S913 S921, S927, T929, S934, Y965, Y989, Y1023, S1031, Y1051, S1060, T1064, T1070, T1073, Y1080, Y1085	T895, Y896, S913, S921, S927, S929, Y949, Y953, Y989, Y1002, S1013, Y1023, S1029, S1031, Y1041, Y1051, S1060, T1064, Y1080, Y1085
TRP	Y1100, S1107, Y016, Y1122, S1036, S1040, S1141	Y1100, S1107, Y016, Y1122, S1036, S1040, S1141
C-terminus	T1154, S1155, T1163, Y1181, S1191, S12551, S1258, T1265, S1269, S1271, S1292, T1296, S1298, S12991, S13001, S1308, S13491, S1350, S13601, S1587, S1888, S1590, Y1826, T18271, S1839, S1848, T1849, T1855	T1154, S1155, T1163, Y1181, S1191, S1193, S12551, S1258, T1265, S1269, S1271, S1292, T1296, S1298, S12991, S13001, S1308, S13491, S1350, S1357, S13601, T1580, S1587, S1588, S1590, Y1826, T18271, S1839, S1848, T1849, S1852, T1855, S1857
Coiled coil	T1200, S1208, S12241, S1227, T1242, T1245, T1248, T12501	T1200, Y1220, S12241, S1227, S1230, S1239, T1242, T12501
S/T rich domain	S13861, S1389, S13901, S1394, S13951, S14031, T1404, S1406, S1409, S1412, S14161, T1418, S14451, S1455, S1463, T14661, T1470, Y1479, T1485, T14871, S14881, S14911, T1493, S14951, S14971, S15011, T15021, S15051, S15101, T1524, S1530, T1534, S15401, T1548	S13861, S1389, S13901, S1394, S13951, S14031, T1404, S1406, S1409, S1412, S14161, T1418, Y1426, S14451, T1454, S1455, S1463, T14661, T1470, Y1479, T1485, T14871, S14881, S14911, T1493, S14951, S14971, S15011, T15021, S15051, S15101, T1524, S1530, T1534, S15401, T1548
Dimerization motif	S1553, S15641, S15661	S1553, S15641, S15661
α-kinase domain	S1595, S1597, S1598, S1600, S1612, T1629, S1631, Y1642, S1656, S1657, Y1659, T1663, S16921, Y1695, Y1696, S1709, Y1727, T1738, T1740, S1749, T1756, S1776, S1785	S1592, S1597, S1598, S1600, S1612, T1629, S1638, S1646, S1656, Y1659, T1663, T1682, S16921, Y1695, Y1696, S1709, Y1727, T1738, T1740, S1749, T1752, Y1753, Y1755, T1756, S1776, S1782, S1811

¹Phosphorylated residues modified by the α-kinase domain of transient receptor potential melastatin 6.

TRP: Transient receptor potential.