Transient receptor potential melastatin 6 and transient receptor potential melastatin 6/7 antagonists suppress colon adenocarcinoma HT-29 cells

Table 1 Phosphorylated residue of transient receptor potential melastatin 6 proteins

	Parental HT-29	Spheroid-derived HT-29
N-terminus	S12, S67, S78, Y80, T87, T88, S90, T92, T94, S141, T169, T170, T176, T181, Y228, S243, S246, S274, S282, S302, T380, S386, T398, S407, Y431, S445, Y462, Y479, T481, T509, T530, S552, S558, Y574, S586, S596, T602, Y608, T635, S662, Y697, S705, T706, S743, T756, S820, Y835, Y845, T859, S869	S12, S32, S78, Y80, T87, T88, T94, Y111, Y116, S141, S153, T169, T170, T176, T181, S184, T204, Y228, T230, S236, T239, Y259, S274, S282, T354, S362, T380, S407, S409, Y431, S445, T471, Y506, T509, Y519, Y525, Y529, T530, Y545, S551, S552, S558, Y574, S586, S590, T602, Y645, S655, Y668, S669, S705, T706, S713, S743, T759, S769, S774, S784, S789, S790, S791, S794, S796, S820, Y845, S869 (65)
Channels	T881, S893, T899, T936, S951, T974, S1000, S1006, Y1022, S1038, T1046, Y1053	S876, T881, S893, S907, T913, T915, Y966, T968, T974, Y979, S1008, Y1026, Y1053
TRP	Y1073, S1078, Y1086, Y1089, T1094, Y1095, S1109	Y1073, S1078, S1080, Y1086, Y1089, Y1091, T1094, Y1095
C-terminus	Y1137, S1139, Y1157, S1168, T1231, S1281, S1285, T1322, S1324, S1329, S1349, S1357, T1375, T1391, S1395, S1399, S1736, S1737, T1739, Y1741, S1746, S1747, S1986, T1993, T2011	Y1137, S1139, Y1157, S1168, T1231, S1244, T1245, S1252, S1254, Y1273, S1277, S1281, S1285, T1311, S1332, S1339, Y1341, S1368, T1375, S1736, S1737, T1739, Y1741, S1746, S1747, S1970, Y1984, T1992, S2002, T2011, S2015
Coiled coil	T1176, S1177, T1181, Y1184, S1195, S1200, S1206, T1221, S1226	T1176, S1177, T1181, Y1184, S1195, S1200, S1206, T1221, S1226
S/T rich domain	S1438, S1441, S1458, T1463, S1487, S1498, S1500, S1503, Y1533, S1539, S1541, T1577, T1598, S1603, S1616, S1618, S1623, T1628, S1630, S1633, T1635, T1647, Y1660, S1672, T1679, S1685, S1689, S1690, S1697, S1699, S1702, T1739, Y1741	T1435, S1437, S1467, T1474, S1478, T1479, S1498, S1500, T1523, Y1533, S1539, S1541, S1562, S1563, T1577, S1583, T1589, S1605, Y1622, S1623, T1628, S1630, S1658, S1664, S1669, S1678, T1679, S1685, S1689, S1690, S1697, S1699, S1702, T1739, Y1741
Dimerization motif	Y1710, S1711, S1722, T1724, T1728, Y1731	Y1710, S1711, S1722, T1724, T1728, Y1731
α-kinase domain	S1754, S1757, S1821, T1822, T1843, Y1854, Y1878, Y1880, T1895, T1897, S1908, Y1912, Y1914, T1915, T1932, S1935	S1754, S1759, S1771, S1787, S1790, T1813, T1822, T1843, Y1854, T1855, Y1865, S1868, Y1886, S1908, Y1912, Y1914, T1915, S1944

TRP: Transient receptor potential.