Investigating radiotherapy’s impact on intestinal perforation risk in gastrointestinal tumor patients treated with bevacizumab

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Dec 15, 2025; 17(12): 110621
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.110621

Table 4 Serum tumor marker levels in the two groups, mean ± SD

Group	CA125 (kU/L)		CA153 (U/mL)		CA199 (U/mL)
Group	Before treatment	After treatment	Before treatment	After treatment	Before treatment	After treatment
Bevacizumab + radiotherapy group (n = 35)	31.44 ± 52.33	6.29 ± 1.23^a	18.95 ± 29.55	30.21 ± 3.66^a	50.12 ± 65.88	6.45 ± 1.12^a
Bevacizumab only group (n = 35)	34.73 ± 53.26	7.36 ± 1.42^a	17.53 ± 11.14	35.26 ± 3.85^a	51.33 ± 72.72	9.10 ± 1.32^a
t	0.260	4.474	0.265	7.194	0.073	12.438
P value	0.795	< 0.001	0.792	< 0.001	0.942	< 0.001

^aP < 0.05 vs the group before treatment.

CA: Carbohydrate antigen.

Citation: He WM, Li WS. Investigating radiotherapy’s impact on intestinal perforation risk in gastrointestinal tumor patients treated with bevacizumab. World J Gastrointest Oncol 2025; 17(12): 110621
URL: https://www.wjgnet.com/1948-5204/full/v17/i12/110621.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i12.110621

He WM, Li WS. Investigating radiotherapy’s impact on intestinal perforation risk in gastrointestinal tumor patients treated with bevacizumab. World J Gastrointest Oncol 2025; 17(12): 110621 [PMID: 41480214 DOI: 10.4251/wjgo.v17.i12.110621]

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