©The Author(s) 2025.
World J Gastrointest Oncol. Dec 15, 2025; 17(12): 105800
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.105800
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.105800
Table 1 Demographics and clinical characteristics of late onset colorectal cancer pre (2015-2019) and during coronavirus disease (2020-2023), n (%)
| Characteristics | LOCRC | P value | |
| 2015-2019 (n = 55) | 2020-2023 (n = 83) | ||
| Mean age | 64.76 | 65.3 | - |
| Male | 31 (56.4) | 56 (67.5) | 0.186 |
| Female | 24 (43.6) | 27 (32.5) | - |
| Race | 0.146 | ||
| African Americans | 50 (90.9) | 68 (82.9) | |
| White | 1 (1.8) | 5 (6.1) | |
| Asian | 1 (1.8) | 4 (4.9) | |
| Hispanic | 2 (3.6) | 0 | |
| Others | 1 (1.8) | 5 (6.1) | |
| BMI (kg/m2) | 0.877 | ||
| Underweight < 18.9 | 5 (9.3) | 4 (4.9) | |
| Normal (19-24.9) | 19 (35.2) | 33 (40.7) | |
| Overweight (25-29.9) | 15 (27.9) | 20 (24.7) | |
| Obese (30-34.9) | 15 (27.9) | 24 (29.6) | |
| Smoking | 22 (40.7) | 37 (44.6) | 0.658 |
| Alcohol | 28(33.7) | 22 (40.7) | 0.778 |
| Unemployed | 31 (57.4) | 53 (69.7) | 0.033 |
| Comorbidities | |||
| Hypertension | 37 (68.5) | 49 (59.8) | 0.3 |
| Diabetes | 18 (33.3) | 18 (22) | 1.44 |
| Heart diseases | 6 (11.1) | 13 (15.7) | 0.45 |
| IBD | 0 | 1 (1.2) | 0.42 |
| CKD | 8 (15.1) | 7 (8.4) | 0.23 |
| Ongoing radiation treatment | 7 (13.5) | 14 (17.1) | 0.57 |
| Cholecystectomy | 3 (5.6) | 5 (6.1) | 0.89 |
| Indication for colonoscopy | 0.53 | ||
| Screening | 4 (7.3) | 10 (12) | |
| Surveillance | 9 (16.4) | 19 (22.9) | |
| Diagnostic | 42 (76.4) | 54 (65) | |
| Diagnostic indication | |||
| GI bleeding | 8 (32) | 13 (39.4) | 0.54 |
| Change in bowel habits | 0 | 1 (6.1) | 0.48 |
| Abnormal imaging | 7 (28) | 8 (24.2) | 0.79 |
| Polyp location | |||
| Cecum | 6 (10.9) | 10 (12) | 0.84 |
| Ascending colon | 9 (16.3) | 13 (15.7) | 0.46 |
| Transverse colon | 10 (17.9) | 14 (17) | 0.21 |
| Descending colon | 7 (12.7) | 12 (14.5) | 0.77 |
| Sigmoid colon | 5 (9.1) | 13 (15.7) | 0.26 |
| Rectum | 11 (20) | 17 (20.5) | 0.71 |
| Size of the mass | 0.52 | ||
| < 10 mm | 18 (66.7) | 31 (73.8) | |
| > 10 mm | 9 (33.3) | 11 (26.2) | |
| Colonoscopy withdrawal time (in minutes) | 0.17 | ||
| 6:00-10:00 | 5 (27.8) | 5 (8.2) | |
| 10.01-15:00 | 3 (16.7) | 7 (11.5) | |
| 15.01-20:00 | 4 (22.2) | 16 (26.2) | |
| 20.01-25:00 | 1 (5.6) | 16 (26.2) | |
| 25.01-30:00 | 1 (5.6) | 6 (9.8) | |
| > 30 | 4 (22.2) | 11 (18) | |
| Quality of bowel preparation | 0.61 | ||
| Excellent/good | 43 (95.6) | 53 (80.3) | |
| Adequate | 2 (4.4) | 10 (15.2) | |
| Poor | 0 | 3 (2.7) | |
| Type of associated polyp | |||
| Hyperplastic | 8 (25) | 12 (26.1) | 0.91 |
| Tubular adenoma | 16 (50%) | 29 (64.4) | 0.21 |
| Tubulo-villous | 2 (6.1) | 7 (15.2) | 0.206 |
| Villous | 1 (3.1) | 0 | 0.233 |
| Sessile serrated | 5 (15.2) | 0 | 0.07 |
| Type of carcinoma | 0.08 | ||
| Adenocarcinoma | 38 (80.9) | 51 (76.1) | |
| Small cell carcinoma | 1 (2.1) | 7 (10.4) | |
| Neuroendocrine tumor | 7 (14.9) | 4 (6) | |
| Previous colonoscopy | 10 (18.2) | 23 (27.7) | |
| Metastasis | 24 (55.8) | 26 (38.2) | 0.07 |
- Citation: Chirumamilla LG, Brim H, Challa SR, Oskrochi G, Deverapalli M, Rashid R, Rashid M, Aduli F, Kibreab A, Laiyemo A, Sherif ZA, Shayegh N, Shokrani B, Zafar R, Carethers JM, Ashktorab H. Early and late-onset colorectal cancer in African Americans during COVID-19. World J Gastrointest Oncol 2025; 17(12): 105800
- URL: https://www.wjgnet.com/1948-5204/full/v17/i12/105800.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v17.i12.105800