Tumour chemotherapy sensitivity test may predict clinical outcomes in colorectal cancer patients receiving oxaliplatin and fluoropyrimidine-based regimens

doi:10.4251/wjgo.v17.i11.111171

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Nov 15, 2025; 17(11): 111171
Published online Nov 15, 2025. doi: 10.4251/wjgo.v17.i11.111171

Table 2 Summary of the chemosensitivity to chemotherapy regimens (n = 1549)

Drugs	n	Level of chemosensitivity				Sensitivity rate (%)
Drugs	n	Strong	Partial	Weak	Resistant	Sensitivity rate (%)
5-FU + L-OHP	1474	22	153	1	1298	11.9
5-FU + SN-38	1474	48	217	1	1208	18.0
5-FU	75	1	3	0	71	5.3
L-OHP	75	1	3	0	71	5.3
SN-38	75	2	10	0	63	16.0

Strong sensitivity, IC₉₀ ≤ 100% test drug concentration (TDC) and IC₅₀ ≤ 25% TDC; partial sensitivity, IC₉₀ > 100% TDC and IC₅₀ ≤ 25% TDC; weak sensitivity, IC₉₀ ≤ 100% TDC and IC₅₀ > 25% TDC; resistant, IC₉₀ > 100% TDC and IC₅₀ > 25% TDC. 5-FU: 5-fluorouracil; L-OHP: Oxaliplatin; SN-38: Irinotecan.

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Citation: Li SJ, Lu YX, Zheng FY, Bian YC, Miao LY, Huang CR. Tumour chemotherapy sensitivity test may predict clinical outcomes in colorectal cancer patients receiving oxaliplatin and fluoropyrimidine-based regimens. World J Gastrointest Oncol 2025; 17(11): 111171
URL: https://www.wjgnet.com/1948-5204/full/v17/i11/111171.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i11.111171

Li SJ, Lu YX, Zheng FY, Bian YC, Miao LY, Huang CR. Tumour chemotherapy sensitivity test may predict clinical outcomes in colorectal cancer patients receiving oxaliplatin and fluoropyrimidine-based regimens. World J Gastrointest Oncol 2025; 17(11): 111171 [PMID: 41281494 DOI: 10.4251/wjgo.v17.i11.111171]

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