Stromal secreted protein acidic and rich in cysteine expression: A potential target for improved prognosis in patients with pancreatic cancer

Table 4 Univariate and multivariate Cox regression analysis of factors affecting overall survival

Variables (n = 91)	Univariate		Multivariate
	HR (95%CI)	P value	HR (95%CI)	P value
Location	0.985 (0.533-1.818)	0.961
Tumor size
≤ 3.0	1.00
> 3.0	1.644 (0.854-3.163)	0.137
N status		0.040		0.007
N0	1.00		1.0
N1	2.388 (1.217-4.689)	0.011	3.137 (1.527-6.444)	0.002
N2	1.691 (0.598-4.783)	0.322	1.761 (0.609-5.088)	0.296
CA19-9
≤ 35	1.00
> 35	1.228 (0.618-2.441)	0.554
Cell differentiation		0.250
Well	1.0
Moderately	0.553 (0.268-1.138)	0.108
Poorly	0.734 (0.250-2.153)	0.573
Lymphovascular invasion	1.009 (0.516-1.972)	0.978
Perineural invasion	0.806 (0.413-1.573)	0.528
Adjuvant therapy			1.0
None	1.0
Done	0.236 (0.123-0.452)	< 0.001	0.151 (0.074-0.306)	< 0.001
SPARC			1.0
Stroma (-)	1.0
Stroma (+)	2.335 (1.255-4.345)	0.007	2.726 (1.441-5.158)	0.002
SPARC adjuvant therapy			1.367 (0.749-2.497)	0.309

SPARC: Secreted protein acidic and rich in cysteine; CA19-9: Carbohydrate antigen 19-9; HR: Hazard ratio; CI: Confidence interval.