Myc-associated zinc finger protein drives colorectal cancer metastasis through activating ubiquitin like with ring finger protein one

doi:10.4251/wjgo.v17.i11.109481

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Nov 15, 2025; 17(11): 109481
Published online Nov 15, 2025. doi: 10.4251/wjgo.v17.i11.109481

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Figure 6 Molecular mechanisms by which Myc-associated zinc finger protein promotes colorectal cancer progression. In colorectal cancer cells, Myc-associated zinc finger protein transcription activates ubiquitin-like with PHD and RING finger domains 1 and promotes esophageal cancer-related gene 4 DNA methylation leading to colorectal cancer tumor metastasis. CRC: Colorectal cancer; MAZ: Myc-associated zinc finger protein; UHRF1: Ubiquitin-like with PHD and RING finger domains 1; ECRG4: Esophageal cancer-related gene 4; EMT: Epithelial-mesenchymal transition.

Citation: Mao HQ, Yu FC, Hu DQ, Zhang LJ. Myc-associated zinc finger protein drives colorectal cancer metastasis through activating ubiquitin like with ring finger protein one. World J Gastrointest Oncol 2025; 17(11): 109481
URL: https://www.wjgnet.com/1948-5204/full/v17/i11/109481.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i11.109481

Mao HQ, Yu FC, Hu DQ, Zhang LJ. Myc-associated zinc finger protein drives colorectal cancer metastasis through activating ubiquitin like with ring finger protein one. World J Gastrointest Oncol 2025; 17(11): 109481 [PMID: 41281490 DOI: 10.4251/wjgo.v17.i11.109481]

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