Gut microbiota and metabolite changes in metastatic colorectal cancer via 16S rRNA and metabolomics

Figure 14  Top 30 significantly enriched pathways of differential metabolites. The X-axis represents the negative logarithmic transformation of the P value, and the Y-axis displays the pathway names. The pathways are categorized into level 1 classifications, with pathways in each category arranged from top to bottom in descending order of significance [i.e., -log₁₀ (P value) decreases, meaning the P value increases and significance declines]. The size of the circles corresponds to the count (number of differential metabolites annotated to the pathway); the color gradient (red to blue) reflects the adjusted P value, with red indicating higher significance. ABC: Adenosine triphosphate-binding cassette; BH: Benjamini-Hochberg method; E: Environmental information processing; G: Genetic information processing; H: Human diseases; M: Metabolism; O: Organismal systems.