Sleep disorders in hepatocellular carcinoma

doi:10.4251/wjgo.v17.i10.110503

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Oct 15, 2025; 17(10): 110503
Published online Oct 15, 2025. doi: 10.4251/wjgo.v17.i10.110503

Table 1 Impacts of different types of sleep disorders on liver cancer

Ref.	Country	Type of sleep disorders	Type of cancer	Outcomes
[13]	United Kingdom	Insomnia	HCC	HR: 1.46, 95%CI: 1.15-1.85
[14]	United States	Insomnia	HCC	HR: 2.00, 95%CI: 1.22-3.26
		Long sleep durations	HCC	HR: 1.63, 95%CI: 1.04-2.65
		Daytime napping	HCC	HR: 1.46, 95%CI: 1.04-2.06
[4]	China	Obstructive sleep apnea	Liver cancer	RR: 1.19, 95%CI: 1.10-1.29
[26]	United States	Circadian rhythm disruption	HCC	IRR: 1.07; 95%CI: 1.01-1.14

Summary of epidemiological studies investigating associations between specific sleep disorders and liver cancer risk, categorized by disorder type, geographic region, and reported effect measures (hazard ratios, relative risks, or incidence rate ratios with 95%CI): Insomnia, prolonged sleep duration, daytime napping, obstructive sleep apnea and circadian rhythm disruption increase the risk of liver cancer. HR: Hazard ratio; RR: Relative risk; IRR: Incidence rate ratio; HCC: Hepatocellular carcinoma.

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Citation: Qian J, Ruan MH, Wang ZJ, Dong W, Jia JY, Feng XC, Liu H. Sleep disorders in hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(10): 110503
URL: https://www.wjgnet.com/1948-5204/full/v17/i10/110503.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i10.110503

Qian J, Ruan MH, Wang ZJ, Dong W, Jia JY, Feng XC, Liu H. Sleep disorders in hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(10): 110503 [PMID: 41114114 DOI: 10.4251/wjgo.v17.i10.110503]

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