Helicobacter pylori-induced miR-136 is a potential predictor of early-stage gastric cancer

doi:10.4251/wjgo.v17.i10.109744

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Oct 15, 2025; 17(10): 109744
Published online Oct 15, 2025. doi: 10.4251/wjgo.v17.i10.109744

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Figure 4 miR-136 promoted the proliferation and migration of Helicobacter pylori-positive gastric cancer cells in vitro. A and B: The expression of miRNA-136 was increased in SGC-7901 and BGC-823 gastric cancer cells transfected with miR-136 mimic, and the expression of miRNA-136 was decreased in SGC7901 and BGC-823 gastric cancer cells transfected with miR-136 inhibitor; C-I: MiR-136 mimic significantly promoted the proliferation and migration of SGC-7901 and BGC-823 gastric cancer cells. Conversely, the miR-136 inhibitor had the opposite effect on SGC-7901 and BGC-823 gastric cancer cells via cell counting kit-8 assay, clone formation, scratch repair assays, and Transwell assay. ^aP < 0.01.

Citation: Chen T, Feng AQ, Shen XR, Dang NY, Ye F, Zhang GX. Helicobacter pylori-induced miR-136 is a potential predictor of early-stage gastric cancer. World J Gastrointest Oncol 2025; 17(10): 109744
URL: https://www.wjgnet.com/1948-5204/full/v17/i10/109744.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i10.109744

Chen T, Feng AQ, Shen XR, Dang NY, Ye F, Zhang GX. Helicobacter pylori-induced miR-136 is a potential predictor of early-stage gastric cancer. World J Gastrointest Oncol 2025; 17(10): 109744 [PMID: 41114105 DOI: 10.4251/wjgo.v17.i10.109744]

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