Helicobacter pylori-induced miR-136 is a potential predictor of early-stage gastric cancer

Figure 1 miR-136 upregulation in Helicobacter pylori-positive human precursor lesions of gastric cancer and gastric cancer tissues. A-D: Overexpressed miRNA-136 and under expressed PDCD11 in Helicobacter pylori (H. pylori)-positive gastric cancer (GC) tissues compared with H. pylori-negative GC tissues; E and F: The expression of miR-136 was negatively related to the expression of PDCD11 in GC tissues (r1 = -0.782; r2 = -0.812); G-K: MiR-136 expression was upregulated and PDCD11 expression was downregulated significantly in precursor lesions of GC compared with non-active gastritis, chronic gastritis, and GC compared with non-active gastritis, chronic gastritis, precursor lesions of GC. ^aP < 0.01. HP+: With Helicobacter pylori infection; HP-: Without Helicobacter pylori; NAG: Non-active gastritis without Helicobacter pylori infection; CAG: Chronic gastritis with Helicobacter pylori-infection; PLGC: Precursor lesions of gastric cancer with Helicobacter pylori-infection; GC: Gastric cancer.