Lipid metabolic reprogramming in colorectal cancer: Insights to mechanisms and therapeutics

Figure 1 Schematic overview of high-fat diet-induced pathological remodeling in the intestinal microenvironment. High-fat foods promote microbial dysbiosis and metabolic reprogramming, leading to stem cell expansion, lipid accumulation, and immunosuppression. LPC: Lysophosphatidylcholine; LPA: Lysophosphatidic acid; PPAR: Peroxisome proliferator-activated receptor; EMT: Epithelial-mesenchymal transition; IFN: Interferon; TNF: Tumor necrosis factor; PD-1: Programmed cell death protein 1; CD: Cluster of differentiation; SREBP: Sterol regulatory element-binding protein; LDL: Low-density lipoprotein; MAPK: Mitogen-activated protein kinase.