Intensive care unit outcomes and prognostic factors of colorectal cancer

Table 2 Multivariate regression analysis of predictors for 90-day survival of intensive care unit admitted colorectal cancer patients

Variables, demographics	Univariate analysis1		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age (years)	0.99 (0.96, 1.03)	0.643
Gender
Female	Reference
Male	0.82 (0.35, 1.94)	0.658
BMI (kg/m2)	0.97 (0.86, 1.08)	0.549
Treatment history
Target therapy	5.43 (2.23, 13.22)	< 0.001
Immunotherapy	-	-
Chemotherapy	3.38 (1.46, 7.80)	0.004	2.66 (1.04, 6.80)	0.041a
Radiotherapy	2.18 (0.51, 9.28)	0.294
Transferring source
Operation room	Reference
Emergency department	3.85 (0.45, 32.96)	0.218
Clinical ward	6.65 (2.41, 18.30)	< 0.001
Other hospitals	-	-
Unplanned transfer	3.83 (1.42, 10.31)	0.008
Elective or emergency surgery
No surgery	Reference
Elective	0.10 (0.04, 0.25)	< 0.001	0.20 (0.07, 0.58)	0.003a
Emergency	0.15 (0.04, 0.68)	0.013	0.26 (0.06, 1.24)	0.091
Severity scores
SOFA	1.19 (1.10, 1.30)	< 0.001
APACHE II	1.12 (1.07, 1.17)	< 0.001	1.06 (1.00, 1.12)	0.071
ICU diagnosis
Sepsis	4.16 (1.42, 12.24)	0.010
ARDS	1.59 (0.47, 5.37)	0.451
Respiratory failure	2.46 (1.08, 5.62)	0.032
AKI	5.16 (2.12, 12.56)	< 0.001
Shock	2.41 (1.06, 5.46)	0.035
Anti-infection treatment
Carbapenems	3.10 (1.36, 7.07)	0.007
β-lactam	1.42 (0.61, 3.28)	0.411
Glycopeptides	2.19 (0.86, 5.56)	0.098
Tigecycline	1.84 (0.43, 7.85)	0.410
Echinocandins	4.19 (0.56, 31.13)	0.161	0.15 (0.01, 1.43)	0.099
Triazoles	3.95 (1.17, 13.31)	0.027
Other treatment
Mechanical ventilation	1.41 (0.62, 3.20)	0.410
Conventional oxygen therapy	0.15 (0.06, 0.38)	< 0.001	0.21 (0.07, 0.62)	0.005a
Sedation treatment	2.03 (0.88, 4.70)	0.097

^aP < 0.05.

¹In the univariate analysis section, blank sections for the variables immunotherapy and transferring source represent confidence intervals of no significance.

HR: Hazard ratio; CI: Confidence interval; BMI: Body mass index; SOFA: Sequential organ failure assessment; APACHE: Acute physiology and chronic health evaluation; ICU: Intensive care unit; ARDS: Acute respiratory distress syndrome; AKI: Acute kidney injury.