Molecular mechanism of modified Yigong San formula against colorectal cancer via EZH2/METTL3/SOX4 pathway-mediated apoptosis

Figure 4 The mRNA expression levels of enhancer of zeste homolog 2, methyltransferase-like 3, SRY-box transcription factor 4, B-cell lymphoma 2, and Bax in different cell groups. A: Enhancer of zeste homolog 2 mRNA expression level; B: Methyltransferase-like 3 mRNA expression level; C: SRY-box transcription factor 4 mRNA expression level; D: B-cell lymphoma 2 mRNA expression level; E: Bax mRNA expression level. ^aP < 0.0001; ^cP < 0.0001; ^bP < 0.05; ^dP < 0.0001; ^eP < 0.0001. SOX4: SRY-box transcription factor 4; METTL3: Methyltransferase-like 3; EZH2: Enhancer of zeste homolog 2; Bcl2: B-cell lymphoma 2; NC: Negative control; YGS: Yigong San; OE: Overexpressing.