Molecular mechanism of modified Yigong San formula against colorectal cancer via EZH2/METTL3/SOX4 pathway-mediated apoptosis

Figure 3 Expression levels of enhancer of zeste homolog 2, methyltransferase-like 3, SRY-box transcription factor 4, B-cell lymphoma 2, and Bax proteins in different groups. A: SRY-box transcription factor 4 protein expression level; B: Methyltransferase-like 3 protein expression level; C: Enhancer of zeste homolog 2 protein expression level; D: B-cell lymphoma 2 protein expression level; E: Bax protein expression level; F: Protein expression images of GAPDH, enhancer of zeste homolog 2, methyltransferase-like 3, SRY-box transcription factor 4, Bax, and B-cell lymphoma 2. ^aP < 0.01; ^bP < 0.01; ^cP < 0.01; ^dP < 0.01; ^eP < 0.0001; ^fP < 0.0001; ^gP < 0.0001. SOX4: SRY-box transcription factor 4; METTL3: Methyltransferase-like 3; EZH2: Enhancer of zeste homolog 2; Bcl2: B-cell lymphoma 2; NC: Negative control; YGS: Yigong San; OE: Overexpressing.