Effect of perioperative chemotherapy on resection of isolated pulmonary metastases from colorectal cancer: A single center experience

Table 1 Clinical, radiological, and histological characteristics of the patient population, n (%)

Factors	Total
Sex
Male	73 (60.8)
Female	47 (39.2)
Age at primary cancer
Median (IQR)	59.10 (51.75-67.25)
DFI
Median (IQR)	2.47 (1.22-3.20)
Age at time of pulmonary surgery
Median (IQR)	62.00 (55.00-70.00)
Pulmonary metastasis
Synchronous	12 (10.0)
Metachronous	108 (90.0)
Access
Open	25 (20.8)
VATS	95 (79.2)
Type of resection
Sublobar resection	70 (58.3)
Lobectomy	50 (41.7)
Lymph node dissection
No	66 (55.0)
Yes	54 (45.0)
Perioperative chemotherapy
No	66 (55.0)
Yes	54 (45.0)
Primary tumor T stage
T1	3 (3.5)
T2	8 (9.3)
T3	62 (72.1)
T4	13 (15.1)
Primary tumor N stage
N0	37 (40.7)
N1 or N2	54 (59.3)
Primary tumor location
Left colon	35 (32.4)
Right colon	19 (17.6)
Rectum	54 (50.0)
Adjuvant chemotherapy for CRC
No	35 (29.2)
Yes	85 (70.8)
CEA levels
≤ 5 ng/mL	62 (61.4)
> 5 ng/mL	39 (38.6)
Number of metastatic lesions
1	96 (80.0)
2	11 (9.2)
3	12 (10.0)
5	1 (0.8)
Tumor size (cm)
≤ 2 cm	63 (53.8)
> 2 cm	54 (46.2)
CRC differentiation
Well/well-to-moderate	11 (12.2)
Moderate	76 (84.4)
Moderate-to-poor/poor	3 (3.3)
Smoking history
No	86 (71.7)
Yes	34 (28.3)
RAS
Wild type	14 (53.8)
Mutant type	12 (46.2)
Bilateral pulmonary nodules
No	113 (94.2)
Yes	7 (5.8)
LN sampling at PM
No	66 (55.0)
Yes	54 (45.0)
Positive LN at PM
No	112 (93.3)
Yes	8 (6.7)
CRC LVI
No	58 (84.1)
Yes	11 (15.9)
CRC PNI
No	50 (72.5)
Yes	19 (27.5)

CRC: Colorectal cancer; CEA: Carcinoembryonic antigen; LN: Lymph nodes; PM: Pulmonary metastases; LVI: Lymphovascular invasion; PNI: Perineural invasion.