Epidemiology and prognostic nomogram for locally advanced gastric signet ring cell carcinoma: A population-based study

Table 1 Baseline clinical characteristics of postoperative locally advanced gastric signet ring cell carcinoma patients

Characteristic	LAGSRC (n = 3793)		P value2
	Untreated/unknown n = 12101	Chemotherapy, n = 25831
Age (yr)	66 (14)	57 (13)	< 0.001
Sex			0.039
Female	621 (51)	1233 (48)
Male	589 (49)	1350 (52)
Year of diagnosis			< 0.001
2000-2003	411 (34)	582 (23)
2004-2007	388 (32)	742 (29)
2008-2011	246 (20)	656 (25)
2012-2015	165 (14)	603 (23)
Race			0.34
White	832 (69)	1718 (67)
Black	139 (11)	304 (12)
Other	239 (20)	561 (22)
Tumor size (cm)			0.92
< 2	59 (4.9)	134 (5.2)
2-5	440 (36)	937 (36)
> 5	495 (41)	1035 (40)
Unknown	216 (18)	477 (18)
Grade			0.19
G1/G2	42 (3.5)	63 (2.4)
G3/G4	1101 (91)	2378 (92)
Unknown	67 (5.5)	142 (5.5)
Primary site			< 0.001
Body	118 (9.8)	257 (9.9)
Cardia	116 (9.6)	371 (14)
Fundus	26 (2.1)	66 (2.6)
Gastric antrum	364 (30)	690 (27)
Greater curvature	46 (3.8)	160 (6.2)
Lesser curvature	171 (14)	330 (13)
Pylorus	68 (5.6)	129 (5.0)
Overlapping lesion	139 (11)	317 (12)
Unknown	162 (13)	263 (10)
PT 8th			< 0.001
T1	55 (4.5)	103 (4.0)
T2	65 (5.4)	171 (6.6)
T3	392 (32)	954 (37)
T4a	387 (32)	838 (32)
T4b	311 (26)	517 (20)
PN 8th			0.067
N0	220 (18)	398 (15)
N1	234 (19)	466 (18)
N2	243 (20)	596 (23)
N3a	324 (27)	731 (28)
N3b	189 (16)	392 (15)
Pathologic stage			0.5
IB	33 (2.7)	64 (2.5)
IIA	152 (13)	307 (12)
IIB	159 (13)	340 (13)
IIIA	257 (21)	622 (24)
IIIB	334 (28)	703 (27)
IIIC	275 (23)	547 (21)
Lymph node count	17 (13)	19 (13)	< 0.001
Radiation status			< 0.001
No/unknown	1120 (93)	983 (38)
Yes	90 (7.4)	1600 (62)

¹Mean (SD); n (%).

²Welch Two Sample t test; Pearson's chi-squared test.

For race, ‘other’ includes American Indian, AK Native, Asian, and Pacific Islander.

LAGSRC: Locally advanced gastric signet ring cell carcinoma; PT: Pathological tumor stage; PN: Pathological node stage.