METTL5 promotes gastric cancer progression via sphingomyelin metabolism

Figure 2 Elevated METTL5 expression were exhibited in patients with gastric cancer. A: Representative immunohistochemistry staining showing METTL5 protein expression in gastric cancer (GC) and paracancerous tissue tissues; B: Staining intensity score of METTL5 in GC tissue microarray; C: Higher expression of METTL5 implied poorer prognosis; D: Western blot of METTL5 and TRMT112 expression in 5 pairs of GC and paracancerous tissue; E and F: The RNA expression of METTL5 and TRMT112 in 5 pairs of GC and paracancerous tissue; G: Western blot of METTL5 expression in gastric mucosal epithelial cells as well as 5 types of GC cells; H: The m6A methylation was measured by m6A RNA Methylation Assay in 5 pairs of GC and paracancerous tissue. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.