METTL5 promotes gastric cancer progression via sphingomyelin metabolism

Figure 1 Elevated METTL5 expression is associated with worse survival of patients with gastric cancer. A: METTL5 expression in normal tissues from GTEx and The Cancer Genome Atlas (TCGA) databases and pan-tumor tissues from TCGA; B: METTL5 expression in normal tissues from the GTEx and TCGA databases and gastric cancer (GC) tissues from TCGA; C: TRMT112 expression in normal tissues from the GTEx and TCGA databases and pan-tumor tissues from TCGA; D: TRMT112 expression in normal tissues from the GTEx and TCGA databases and in GC tissues from TCGA; E: Correlation between METTL5 and TRMT112 in the TCGA; F: Analysis of METTL5 and overall survival of patients in the TCGA dataset; G: Analysis of TRMT112 and overall survival of patients in the TCGA dataset; H-J: Association of METTL5 levels with tumor grade, tumor stage, and lymph node metastasis of GC from TCGA database. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.