Two missense STK11 gene variations impaired LKB1/adenosine monophosphate-activated protein kinase signaling in Peutz-Jeghers syndrome

Figure 5 Expression of the adenosine monophosphate-activated protein kinase in polyps of Peutz-Jeghers syndrome and non-Peutz-Jeghers syndrome patients. A-D: The phosphorylation levels of adenosine monophosphate-activated protein kinase in Peutz-Jeghers (PJS) patients polyps were significantly lower than those in non-PJS patients polyps. Magnification: 70 ×. Results of independent samples were calculated by using five randomly selected visual fields. Independent sample results were obtained after at least three experiments and then obtained statistically. PJS: Peutz-Jeghers syndrome; AMPK: Adenosine monophosphate-activated protein kinase. ^cP < 0.0001.