Two missense STK11 gene variations impaired LKB1/adenosine monophosphate-activated protein kinase signaling in Peutz-Jeghers syndrome

Figure 4 Expression of the serine/threonine kinase 11 in polyps of Peutz-Jeghers syndrome and non-Peutz-Jeghers syndrome patients. A-D: The phosphorylation levels of liver kinase B1 in Peutz-Jeghers syndrome (PJS) patients polyps were significantly lower than those in non-PJS patients polyps. PJS: Peutz-Jeghers syndrome; LKB1: Liver kinase B1. ^aP < 0.05; ^bP < 0.001; ^cP < 0.0001.