Human β-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long non-coding RNA TCONS_00014506

Figure 1 Human β-defensin-1 affects the viability, clonogenesis, and autophagy of SW620 cells. A: Human β-defensin-1 (hBD-1) suppresses cell viability; B: hBD-1 inhibits clonal formation; C: Clonal formation count; D: hBD-1 inhibits phosphorylation of mTOR and promotes expression of Beclin-1 and LC3II/I; E-G: Relative expression of p-mTOR, Beclin-1, and LC3II/I. ^aP < 0.05 vs control group. hBD-1: Human β-defensin-1.