Curcumin inhibits the growth and invasion of gastric cancer by regulating long noncoding RNA AC022424.2

Figure 4 Analysis of differentially expressed genes and lncRNAs between the curcumin-treated and control groups. A: Volcano plot of differentially expressed genes. Red points indicate upregulated genes [Log2 (fold change)] > 1, P-value < 0.05; blue points represent downregulated genes [Log2 (fold change)] < -1, P-value < 0.05; and black points signify genes without significant differential expression; B: Cluster heatmap of gene expression. The color scale represents the Z-score values, where red indicates high expression and blue indicates low expression. Group 1: Untreated group; Group 2: Curcumin-treated group; C: The expression level of lncRNAs in BGC-823 was detected using quantitative reverse transcription polymerase chain reaction (qRT-PCR); D: The expression of lncRNAs in MGC-803 cells was detected using qRT-PCR. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.