Establishment of a cholangiocarcinoma risk evaluation model based on mucin expression levels

Figure 2 Activated nucleotide metabolic signaling and higher malignant characteristics in MUC1-high tumor cells of cholangiocarcinoma. A: Heatmap showing the activity of metabolic signaling pathways in MUC1-high vs MUC1-low cells; B: Heatmap showing the different expression levels of transcription factors in MUC1-high cells vs MUC1-low cells; C: Distribution of MUC1 and HMGA1 in the spatial transcriptomics (ST) slide. Zoomed in portions of the ST chip (middle) showing multiple areas of co-localization; D and E: Gene set enrichment analysis plots showing the enrichment of genes from MUC1-high cells (left) vs MUC1-low cells (right) in cell proliferation and metastasis signaling pathways. The P values and normalized enrichment score are indicated on the plots.