Risk factors for hepatocellular carcinoma associated with hepatitis C genotype 3 infection: A systematic review

Table 4 Pooled individual participant data for all participants with hepatitis C genotype 3 who developed hepatocellular carcinoma

Risk factor	Number of participants
Patient-dependent factors
Cirrhosis	66
Male	118
Female	62
Age > 40 yr	65
Alcohol intake > 40 g/d	56
Anti-HBc	46
Diabetes	25
Age < 50 yr	0
NRAS oncogene	27
Age, per 10-yr increase	0
High BMI	5
Hypertension	3
HBV co-infection	12
Treatment dependent factors
DAA treatment	66
SVR achieved	74
SVR not achieved	13
Decompensated cirrhosis and achieved SVR	1
Use of SOF/DCV/RBV	9
Biochemical factors
Low platelet count	16
High AFP	65
High HCV VL	71
ALP > 68	65
HCV viraemia	58
MELD-score > 9.5	16

HBc: Hepatitis B virus core protein; BMI: Body mass index; DAA: Direct-acting antiviral; SVR: Sustained virologic response; SOF: Sofosbuvir; DCV: Daclatasvir; RBV: Ribavirin; HBV: Hepatitis B virus; HCV: Hepatitis C virus; AFP: Alpha feto protein; MELD: Model for end-stage liver disease; VL: Viral load.