Clinical and socioeconomic determinants of survival in biliary tract adenocarcinomas

Table 2 Associations of baseline characteristics and clinical factors with 5-year survival outcomes following diagnosis using multivariate Cox regression analysis

Parameter	Hazard ratio	95%CI	P value
Site
Ampullary carcinoma	1
Intrahepatic bile duct carcinoma	2.17	2.08-2.25	< 0.0001
Extrahepatic bile duct carcinoma	1.87	1.80-1.94	< 0.0001
Gallbladder carcinoma	1.68	1.62-1.74	< 0.0001
Sex
Female	1
Male	1.07	1.05-1.10	< 0.0001
Race/ethnicity
White	1
American Indian/Alaska native	1.02	0.93-1.13	0.64
Asian or Pacific Islander	0.93	0.90-0.96	< 0.0001
Black	1.05	1.01-1.09	0.03
Hispanic	0.97	0.93-0.99	0.03
Age
≤ 60 yr	1
> 60 yr	1.31	1.28-1.35	< 0.0001
Stage
Local	1
Regional	1.29	1.42-1.56	< 0.0001
Distant	3.02	2.88-3.16	< 0.0001
Unknown	1.90	1.81-2.00	< 0.0001
Grade
Well differentiated, I	1
Moderately differentiated, II	1.39	1.33-1.46	< 0.0001
Poorly differentiated, III	2.17	2.07-2.28	< 0.0001
Undifferentiated; anaplastic, IV	2.22	1.99-2.48	< 0.0001
Marital status
Married	1
Divorced	1.13	1.08-1.17	< 0.0001
Single, never married	1.13	1.09-1.17	< 0.0001
Widowed	1.19	1.15-1.22	< 0.0001
Unknown	0.99	0.93-1.05	0.63
Year of Diagnosis
1975-1990	1
1991-2005	0.89	0.85-0.92	< 0.0001
2006-2016	0.88	0.83-0.92	< 0.0001
Chemotherapy
Yes	1
No/unknown	1.34	1.31-1.38	< 0.0001
Surgery
Yes	1
No/unknown	1.30	1.23-1.37	< 0.0001
Radiation
Yes	1
No/unknown	1.02	0.98-1.07	0.26