Expression and significance of pigment epithelium-derived factor and vascular endothelial growth factor in colorectal adenoma and cancer

Figure 4 Immunohistochemistry of vascular endothelial growth factors in three groups. A: Vascular endothelial growth factors (VEGF) immunohistochemistry (IHC) plot in normal group (IHC × 100); B: VEGF immunohistochemistry plot in normal group (IHC × 200). In the normal group, the cytoplasm of the study cells was not colored and showed negative (-) expression; C: VEGF immunohistochemistry plot in adenoma group (IHC × 100); D: VEGF immunohistochemistry plot in adenoma group (IHC × 200). In the adenoma group, the cytoplasm was light yellow, the number of positive cells was more than 75%, and the expression was weak positive (+); E: VEGF immunohistochemistry plot in colorectal cancer (CRC) group (IHC × 100); F: VEGF immunohistochemistry plot in CRC group (IHC × 200). In the CRC group, the cytoplasm was expressed in yellow fine particles on the surface of the tumor cell cavity, and the number of positive cells was greater than 75%, showing moderately positive (++) expression. Note: In the normal group, adenoma group and CRC group, the expression of brown or yellow was widely seen in the colorectal stromal cells and vascular endothelial cells, which was used as a positive internal control. VEGF: Vascular endothelial growth factors.