Preoperative controlling nutritional status as an optimal prognostic nutritional index to predict the outcome for colorectal cancer

Table 3 Uni- and multi-variate analyses of factors associated with 3-year overall survival in patients with colorectal cancer

Variable		Univariate analysis			Multivariate analysis
		HR	95%CI	P value	HR	95%CI	P value
Age (yr)	≥ 65/< 65	1.815	0.738-4.468	0.194
Sex	Female/male	1.577	0.641-3.881	0.321
BMI (kg/m2)	≥ 24/ < 24	0.202	0.047-0.873	0.032	0.506	0.103-2.474	0.400
Tumor site	Colon/rectum	0.931	0.374-2.314	0.877
Comorbidities	Yes/no	2.557	0.745-8.777	0.136
Sarcopenia	Yes/no	8.012	3.151-20.372	< 0.01	3.640	1.182-11.207	0.024
WBC (× 109/L)	≥ 10/< 10	1.228	0.164-9.202	0.841
Platelet (× 109/L)	≥ 300/< 300	0.798	0.184-3.454	0.763
Hemoglobin (g/L)	≥ 90/< 90	0.367	0.132-1.019	0.054	0.696	0.234-2.071	0.515
CRP (mg/L)	> 10/≤ 10	1.647	0.381-7.130	0.504
CEA (ng/mL)	≥ 3.4/< 3.4	2.319	0.881-6.101	0.088	1.970	0.708-5.480	0.194
CA199 (U/mL)	≥ 37/< 37	1.903	0.254-14.257	0.531
Postoperative complications	Yes/no	1.028	0.300-3.529	0.965
TNM stage	Ⅲ/Ⅰ,Ⅱ	4.167	1.501-11.571	0.006	4.396	1.534-12.598	0.006
CONUT score	≥ 5/≤ 4	5.939	2.386-14.785	< 0.01	3.920	1.330-11.547	0.013

95%CI: 95% confidence interval; HR: Hazard ratio; BMI: Body mass index; WBC: White blood cell; CEA: Carcinoembryonic antigen; CA199: Carbohydrate antigen 199; CONUT: Controlling nutritional status; CRP: C-reactive protein.